The present study evaluates nootropic activity of Solanum torvum in mice. Y-maze, T-maze, open field apparatus, novel object recognition test apparatus are some of the behavioral models which were used to evaluate various parameters such as number of arm entries and percent alterations, locomotor activity, grooming, rearing behavior and discrimination index respectively. The animals were divided into different groups and received different doses of S. torvum methanolic extract (STME-30 mg/kg and 100 mg/kg) and its isoflavonoid rich fraction (IRF-10 mg/kg and 30 mg/kg). S. torvum extract and fraction were combined with sildenafil (8 mg/kg). All the treatment groups were compared with control group. Results were analyzed using a one-way ANOVA followed by a Dunnett’s test and expressed as mean±SEM. A significant increase in percentage alteration in T-maze and Y-maze was observed, whereas open field tests revealed a significant reduction in rearing and grooming behaviors at all doses tested while no significant changes in horizontal locomotion were seen. An increase in discrimination index (D) was observed in novel object recognition test. The experimental results demonstrate that the doses of STME and its IRF in combination with sildenafil possess significant nootropic activity.
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